Which method is considered most accurate for estimating resting energy expenditure in clinical practice?

Which method is considered most accurate for estimating resting energy expenditure in clinical practice?

• A. Direct calorimetry only.
• B. Harris-Benedict equation without activity factor
• C. Indirect calorimetry; if unavailable, use validated equations like Mifflin-St Jeor with activity and stress factors.
• D. Estimating energy needs by body weight alone

Answer: (C)